Fig. 2: A High-LCFA diet exacerbates DSS-induced colitis of WT mice. | Cell Death & Disease

Fig. 2: A High-LCFA diet exacerbates DSS-induced colitis of WT mice.

From: Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis

Fig. 2

A WT Mice (n = 6) were given ND, HPAD, and HSAD for 4 weeks, followed by continuous administration of 3% DSS in drinking water for 7 days in the colitis groups. B Changes in mice body weight. C Changes in DAI; D Representative colon morphology and length with quantification in mice; E Representative images of colon H&E staining. Well-preserved mucosal crypts and villi structure (black arrow), and healthy submucosa with no inflammation (black star); Mucosal erosions, ulceration, and mucosal atrophy (red arrows), and swollen submucosa with inflammatory cell infiltration (red star). F Histological scoring of mice based on colon section morphology; G Comparison of levels of FFAs in mice serum. H Spearman correlation analysis between levels of serum FFAs and pathological histological scoring in mice from the ND + DSS group, HPAD + DSS group, and HSAD + DSS group. I Spearman correlation analysis between levels of serum FFAs and DAI of last day from the ND + DSS group, HPAD + DSS group, and HSAD + DSS group. The data were presented as mean ± SD. P values were determined using one-way or two-way ANOVA test.; ***p < 0.001, **p < 0.01, *p < 0.05.

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