Fig. 1: Expression level of QRICH1 and its prognostic significance.
From: QRICH1 suppresses pediatric T-cell acute lymphoblastic leukemia by inhibiting GRP78
A RNA-seq screened 18 UPR-related differentially expressed genes between pediatric T-ALL cases and controls. B Expression levels of QRICH1 in different human tissues. Downregulated mRNA (C) and protein levels QRICH1 (D) in pediatric T-ALL cells. E Downregulated QRICH1 in pediatric T-ALL and adult T-PLL in the GEO database. F Downregulated QRICH1 in bone marrow samples of incipient pediatric T-ALL than remission samples. G Analysis of the TCGA database showed lower EFS and OS in pediatric T-ALL cases with low QRICH1 expression. H Low expression of QRICH1 in the high-risk subgroups of 23 T-ALL patients in our hospital.
