Fig. 2: STAT6 promotes the progression of UM in vivo and in vitro. | Cell Death & Disease

Fig. 2: STAT6 promotes the progression of UM in vivo and in vitro.

From: STAT6/LINC01637 axis regulates tumor growth via autophagy and pharmacological targeting STAT6 as a novel strategy for uveal melanoma

Fig. 2

A, C The expression level of STAT6 mRNA in UM cells following STAT6 knockdown; (B, D) STAT6 knockdown was used to analyze the expression of STAT6 in UM cells through Western blotting; (E–H) This analysis examined how the knockdown of STAT6 affected the proliferation, migration, and invasion of UM cells.; (I, K) The level of STAT6 mRNA expression in UM cells that were overexpressing STAT6; (J, L) STAT6 overexpression in UM cells was analyzed by Western blotting.; (M–P) A comprehensive analysis of the proliferation, migration, and invasion of UM cells in vitro overexpressing STAT6; (Q) The volume of tumors formed in the LV-NC and LV-STAT6 groups was quantified; (R) The weight of tumors formed in the LV-NC group and the LV-STAT6 group were quantified. S The photographic images of tumors from the LV-NC and LV-STAT6 groups. (Scale bar: 100 µm; Data were presented as the mean ± SD; n = 3–6; *p < 0.05, **p < 0.01, ***p < 0.001).

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