Fig. 7: Downexpression of GMFB partially rescued the bone loss induced by OVX. | Cell Death & Disease

Fig. 7: Downexpression of GMFB partially rescued the bone loss induced by OVX.

From: Glial maturation factor-β deficiency prevents oestrogen deficiency-induced bone loss by remodelling the actin network to suppress adipogenesis of bone marrow mesenchymal stem cells

Fig. 7

A–C Representative images of H&E staining (A) and quantification of adipocyte number (B) and area (C) in rat tibias from Sham, OVX, shControl and shGMFB groups. (scale bars, 100 μm, n = 6). D–G Representative micro-CT images (D) and quantification of trabecular bone volume per tissue volume (Tb.BV/TV) (E), trabecular number (Tb.N) (F) and trabecular separation (Tb.Sp) (G) in tibias (n = 6). H and I Representative images of osteocalcin (OCN) staining (H) and quantification of number of OCN+ cells (red arrows) in tibias (I) (scale bars, 50 μm, n = 6). J–L Representative images of calcein double-labelling (J) and analysis of mineral apposition rates (MARs) (K) and Bone formation rate per unit of bone surface (BFR/BS) (L) of trabecular bone in tibias (scale bars, 50 μm, n = 6).

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