Fig. 1: CYP2J2/EpOMEs are increased in BC patients and MMTV-PyMT mice. | Cell Death & Disease

Fig. 1: CYP2J2/EpOMEs are increased in BC patients and MMTV-PyMT mice.

From: Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFκB1/CXCL9-mediated tumor growth and metastasis

Fig. 1

A Scheme of the clinical study; B OPLS-DA score scatter plots for the metabolic profile of BC patients and healthy controls (n = 33); C S-plot indicated EpOMEs are the major contributing factor to separate BC patients from controls (n = 33); D Plasma EpOMEs were significantly higher for the BC patients than those of healthy controls; Representative IHC images (E) and statistical analyses (F) of CYP2Cs and CYP2J2 expressions in tumor tissues and their para-tumoral tissues (Control) from the patients with different subtypes of BC (n = 10); mRNA (G) and protein (H) expression of CYP2J2 in TNBC cells and normal human mammary epithelial cells; I Scheme of the animal study; J OPLS-DA score scatter plot for metabolic profile of NTBC mice and controls (n = 6). K Plasma EpOMEs were significantly higher for MMTV-PyMT mice than those of control mice; L mRNA expression of Cyp2j8 was significantly increased in the tumor tissues of MMTV-PyMT mice when compared with those of control mice. Data are presented as Mean ± SD. Statistical difference (***P < 0.001, **P < 0.01, *P < 0.05) was determined by Student t-test (normal distribution) or Wilcoxon–Mann–Whitney test.

Back to article page