Fig. 2: Early loss of striatal PKD in R6/1 mouse model of HD.
From: Down-regulation of neuroprotective protein kinase D in Huntington´s disease
Representative immunoblot of PKDT and p-PKD (S916) and quantification of protein levels in homogenates from striatum and cerebral cortex of 3.5- (A) or 7.5-month-old (B) R6/1 (n = 6) and wild type (WT) mice (n = 7) of the same ages. Levels of β-actin were used as loading control for normalization purposes. C qRT-PCR analysis of PRKD1 mRNA from striatum of 3.5-month-old or 7.5-month-old R6/1 (n = 6–7) and WT (n = 6–7) mice. Data are represented as mean ± SEM. *P < 0.05, **P < 0.01 or ***P < 0.001 using unpaired Student’s t test.
