Fig. 7: Proposed mechanisms of ABCA8-mediated GEM ineffectiveness in PC. | Cell Death Discovery

Fig. 7: Proposed mechanisms of ABCA8-mediated GEM ineffectiveness in PC.

From: ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway

Fig. 7

Increased expression of ABCA8 in PC cells fasilitates the efflux of TCA, one conjugated bile acid. Extracellular TCA activates the ERK signaling via the transmembrane receptor S1PR2. The activation of ERK signaling regulates the expressions of the apoptosis-related proteins BAX and BCL2, and then leads to the insensitivity of PC cells to the anticancer drug GEM. Either blockade of S1PR2 by JTE-013 or blockade of ERK signaling by SCH772984 can inhibit the ABCA8-mediated GEM resistance of PC cells.

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