Fig. 2: Proteomics of Ambra1+/gt vs Ambra1+/+ retina.
From: Age related retinal Ganglion cell susceptibility in context of autophagy deficiency
a Heat map depicting the hierarchical clustering of the differentially expressed proteins in the old Ambra1+/+ (WT) and Ambra1+/gt (HT) animals at baseline. Gene names of the proteins are listed. Green indicated proteins significantly downregulated, red indicated proteins significantly upregulated. b Significant toxicological list derived from the IPA analysis of the old Ambra1+/gt (HT) vs. Ambra1+/+ (WT) animals at baseline, after performing Benjamini-Hochberg correction. c Relevant protein clusters statistically significantly differently regulated between Ambra1+/+ (WT) and Ambra1+/gt (HT) animals derived from the String analysis (p < 0.05). The number of proteins belonging to the clusters is displayed. d Alpha-crystallin A-Chain (CRYAA), Alpha-crystallin B-chain (CRYBA) and Beta-crystallin B2 (CRYBB2) protein expressions in Ambra1+/+ and Ambra1+/gt, #p < 0.01.
