Fig. 2: KLF10 was down-regulated in multiple AKI mouse models and 3D renal tubule injury models. | Cell Death Discovery

Fig. 2: KLF10 was down-regulated in multiple AKI mouse models and 3D renal tubule injury models.

From: Downregulation of KLF10 contributes to the regeneration of survived renal tubular cells in cisplatin-induced acute kidney injury via ZBTB7A-KLF10-PTEN axis

Fig. 2

A Flowchart detailing bilateral IR or CLP surgery and cisplatin treatment regime in C57BL/6 J mice. B Representative immunoblot analysis of KLF10 and PCNA in kidney tissues from cisplatin-induced AKI mouse model. ACTIN served as the standard. n = 6 per group. C, D The morphology and injury rate of 3D renal tubular model treated with cisplatin of different concentration. E Representative immunoblot analysis of KLF10 in cisplatin treated 3D renal tubular model. ACTIN served as the standard. F Fluorescence images of 3D tubular cisplatin-induced AKI model (75 μM) at different time points reflecting the injury degree (LM - light microscope and GFP) and proliferative activity (Fucci-overall, Merge and Fucci). ***p < 0.001 vs control group at the same experimental conditions.

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