Fig. 1: NTRK1 knockdown in mouse hippocampus induced cognitive impairment in the mice. | Cell Death Discovery

Fig. 1: NTRK1 knockdown in mouse hippocampus induced cognitive impairment in the mice.

From: NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

Fig. 1

A, B Mice were administered with a stereotactic brain injection of the lentivirus carrying NTRK1 shRNA or shRNA NC in the hippocampus. The WB results suggested that NTRK1 was effectively downregulated upon the lentiviral injection. n = 3. C–E The OFT test results indicated that NTRK1 knockdown increased the immobility duration and reduced the crossing and rearing counts of mice. n = 6. F, G The results of FST test and TST test indicated that NTRK1 knockdown prolonged the immobility duration of the mice. n = 6. H, I Virtual radial arm maze test suggested that NTRK1 knockdown induced the working and reference memory errors of the mice. n = 6. J–L Morris water maze test revealed that NTRK1 knockdown damaged the spatial memory ability of the mice. n = 6. *P < 0.05. **P < 0.01.

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