Fig. 2: NTRK1 knockdown in mouse hippocampus tissue induced neuronal damage, suppressed mitophagy, and inactivated the AMPK/ULK1/FUNDC1 pathway in the mice. | Cell Death Discovery

Fig. 2: NTRK1 knockdown in mouse hippocampus tissue induced neuronal damage, suppressed mitophagy, and inactivated the AMPK/ULK1/FUNDC1 pathway in the mice.

From: NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

Fig. 2

A, B Nissl staining revealed thatNTRK1 knockdown reduced the number of Nissl bodies in the mouse hippocampal CA3 region. n = 3. C–H The results of NeuN, GFAP, and Iba1 IF staining suggested that NTRK1 knockdown reduced the number of NeuN-positive neurons while increasing the number of GFAP and Iba1-positive neurons in mouse hippocampus. n = 3. I–L WB results indicated thatNTRK1 knockdown inactivated the AMPK/ULK1/FUNDC1 pathway and suppressed mitophagy in mouse hippocampus. n = 3. **P < 0.01.

Back to article page