Fig. 4: IGF2 treatment improved motor performance in an idiopathic PD mice model. | Cell Death Discovery

Fig. 4: IGF2 treatment improved motor performance in an idiopathic PD mice model.

From: IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models

Fig. 4

A Experimental strategy to determine the effect of IGF2 gene therapy in idiopathic PD mice model. B Beam test was performed to evaluate spontaneous motor changes associated with dopamine depletion in the striatum of α-syn PFF injected mice. Number of errors for steps was measure and plotted for each condition at basal condition (0 weeks), 6, or 12 weeks. C Dopaminergic innervation was detected using anti-TH antibody (green), in striatum tissue. Total cells were visualized using DAPI staining (blue). FC correspond to fold change. Scale bar = 20 μm. D Medium spine neuron present in the striatum brain region was visualized using anti-DARPP32 antibody (capyso). Phospho -α-syn (p-α-syn) accumulation were visualized in striatum tissue sections by anti-p-α-syn immunostaining (red). Total cells were visualized using DAPI staining (blue). Scale bar = 20 μm. For all experiment mean and SEM were represented for seven independent experiments. Statistically significant differences were detected by two-tailed unpaired t test (*p < 0.05).

Back to article page