Fig. 2: Knocking out EP300 and CREBBP inhibited proliferation of MLL-r cells. | Cell Death Discovery

Fig. 2: Knocking out EP300 and CREBBP inhibited proliferation of MLL-r cells.

From: The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia

Fig. 2

A Western blots of cells knocking out EP300, CREBBP and NT Ctrl cells. B Proliferation analysis with EdU staining of cells knocking out EP300, CREBBP and NT Ctrl. C Quantification of colony forming in EP300, CREBBP knock-out and NT Ctrl cells. D The changes of cell cycle after knocking out EP300 and CREBBP. E, F The proportion of CD11b+CD15+ cells with EP300, CREBBP knocked out and NT Ctrl in MLL-r (E) and MLL-r wild-type (F) cells. NT Ctrl Nontarget Control, KO Knock Out, MLL-r MLL rearrangement, MLL-r cell lines THP-1, Molm13, MLL wild-type cell lines: U-937, HL-60. NS: No Significance.

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