Fig. 7: Schematic diagram of functional regulation of miR-3074-5p on M1 polarization and pyroptosis of decidual macrophages by targeting ERĪ±, leading to adverse pregnancy outcomes. | Cell Death Discovery

Fig. 7: Schematic diagram of functional regulation of miR-3074-5p on M1 polarization and pyroptosis of decidual macrophages by targeting ERĪ±, leading to adverse pregnancy outcomes.

From: Increased miR-3074-5p expression promotes M1 polarization and pyroptosis of macrophages via ERĪ±/NLRP3 pathway and induces adverse pregnancy outcomes in mice

Fig. 7

Abnormally increased miR-3074-5p expression in dMĻ•s at the early pregnancy could directly inhibit ERĪ± expression, and subsequently activate NLRP3 inflammasome by activating NFĪŗB signal pathway or/and promoting the interaction of NLRP3 and ASC, followed by the enhancement of M1 polarization and pyroptosis of dMĻ•s, disturbing the immune-microenvironment at the maternal-fetal interface and finally leading to embryo loss and abnormal fetal development.

Back to article page