Fig. 3: IGF2BP2 positively regulated GSTM5 expression in the synovial tissues of CIA rats.
From: IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis
A Heatmap plot of DEGs between CON and CIA groups. B Heatmap plot of DEGs between CIA and AAV groups. C Venn diagram among 10 down-regulated genes and 28 up-regulated genes. D The mRNA expression of GSTM5 in synovial tissues of rats was detected by qPCR after IGF2BP2 AAV treatment. E The expression of GSTM5 was detected by western blotting in synovial tissues of rats after IGF2BP2 AAV treatment (n = 6 per group). F IHC staining of GSTM5 expression in synovial tissue specimens of different groups. Scale Bar = 800 µm. G Western blotting was used to detect GSTM5 protein level in synovial tissues of OA and RA patients. *P < 0.05, **P < 0.01, ***P < 0.001.
