Fig. 2: Mechanism of necroptosis in NAFLD.
From: Targeting cell death in NAFLD: mechanisms and targeted therapies
Various NAFLD triggering factors can lead to the upregulation of RIPK3, triggering RIPK3-dependent necroptosis, and drugs such as ELA and TTP can inhibit necroptosis and protect against NAFLD by acting on different targets of the necroptosis mechanism.
