Fig. 4: IFNγ could regulate the expression of DNMT3A in keloids.
From: IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A
A The string of protein-protein interactions. B Immunohistochemical staining for IFNγ in normal skin and keloid. C The western blotting results of IFNγ in normal skin and keloid. D The western blotting results of KFs after treated with oe-DNMT1, oe-DNMT3A and oe-DNMT3B for 24 h. E Gene expression of KFs after treated with oe-DNMT1, oe-DNMT3A and oe-DNMT3B for 24 h. F The western blotting results of KFs after treated with si-DNMT1, si-DNMT3A and si-DNMT3B for 24 h. G Gene expression of KFs after treated with si-DNMT1, si-DNMT3A and si-DNMT3B for 24 h. H The western blotting results of IFNγ and DNMT3A after treated with si-IFNγ or oe-IFNγ. Bar=100 μm. *p < 0.05, **p < 0.01, ***p < 0.001.
