Fig. 8: HSP90-WWP1/WWP2-NEDD4L-dCK-ESR1-SLC7A11 axis regulated IR induced ferroptosis axis.

A Inhibition of cellular ferroptosis by the HSP90-WWP1/WWP2-NEDD4L-dCK-ESR1-SLC7A11 axis under normal radiation conditions. B Promotion of cellular ferroptosis by the HSP90-WWP1/WWP2-NEDD4L-dCK-ESR1-SLC7A11 axis after using HSP90 inhibitor (17-AAG) under radiation conditions.