Table 1 CRIP family related cardiovascular disease and expression.
CRIP members | Associated diseases | Expression level | Sample | Disease models or patients | References |
|---|---|---|---|---|---|
CRIP1 | Hypertension | ↑ | Splenic monocytes/macrophages and circulating monocytes | Human cohort study and hypertensive model (mouse) | [51] |
CRIP1 | Hypertension, cardiac hypertrophy, stroke | ↑ | Whole blood and monocyte | Patients with hypertension and atherosclerosis | [57] |
CRIP1 | Cerebral ischemic injury | ↑ | Neurons | Middle cerebral artery occlusion model(rats) | [75] |
CRIP2 | Pathological cardiac hypertrophy | ↓ | H9c2 | Cardiac hypertrophy model and heart failure model(mice) | [15] |
CRIP2 | Myocardial infarction | ↓ | Peripheral Blood | Patients with myocardial infarction | [28] |
CRIP2 | Cardiac dysfunction | ↓ | Zebrafish embryonic heart | / | [59] |
CRIP3 | Hypertension | / | / | Patients with hypertension and atherosclerosis | [60] |
CRIP3 | Tetralogy of Fallot with hyperoxic/standard vs. controlled reoxygenation cardiopulmonary bypass | CRIP3 is upregulated in hyperoxia/standard compared to controlled reoxygenation cardiopulmonary bypass | Ventricular myocardial biopsy | Cyanotic patients undergoing repair of heart defects | [61] |
