Fig. 5: The asymmetrical movement of TM1 and TM6.
From: Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
a Comparison between the outward-occluded structure of LAT1 bound with JX-078 and that bound with Diiodo-Tyr, with the side view, the bottom view, and the top view shown in left, middle, and right panel, respectively. b Structural comparison among the inward-facing structure of LAT1 bound with BCH and the outward-occluded structure of LAT1 bound with JX-078 or Diiodo-Tyr (left panel). The movement of TM1 and TM6 is shown in the middle and right panel, respectively. BCH, JX-078, and Diiodo-Tyr are colored pink, yellow, and lemon green, respectively.
