Fig. 6: Putative working model for the LAT1-4F2hc complex.
From: Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
The model shows a transport mechanism of LAT1. LAT1 loads substrates in cytoplasm and then TM1a and TM6b rotate to the hash ___domain to close the inward gate. During the transition from the inward-facing conformation to the outward-facing conformation, TM1a and TM6b continue to rotate and TM1b and TM6a start to rotate away from the hash ___domain. Then TM1b and TM6a undergo further rotation and push the gating residue Phe252 away from the occluded configuration, triggering substrate release. For simplicity, TM2 and TM7 of the core ___domain and TM8 of the hash ___domain are not shown here. ECD, extracellular ___domain. H, helix. TM, transmembrane helix.
