Fig. 2: Characterization of cardiomyocytes at different stages of FM. | Cell Discovery

Fig. 2: Characterization of cardiomyocytes at different stages of FM.

From: Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Fig. 2

a Numbers of up- and down-regulated genes of CMs at different time points. b, c UMAP embedding of all the CMs colored by clusters (b) and samples (c). d 11 CM subtypes are grouped into 4 FCs by Spearman correlation analysis. FC1 = CM3 + CM8 + CM9, FC2 = CM1 + CM10, FC3 = CM2 + CM5 + CM6, FC4 = CM4 + CM7 + CM11. e Expression of marker genes for each FC. f Cell proportion change of FCs at different time points. g Immunohistochemical staining of the marker genes of each FCs at different time points. Scale bars: 100 μm. h Gene Ontology (GO) analysis of specifically expressed genes in each FC. i Box plot of the cardiac tricarboxylic acid cycle, angiogenesis, and cytokine scores among different FCs. j, k Developmental trajectories of FC1, FC2, FC3, and FC4 colored by pseudotime (j) and FCs (k). l Expression of marker genes for each FC along the developmental trajectory. m Heatmap of regulon activity in each FC.

Back to article page