Fig. 3: Characterization of cardiac neutrophils at different stages of FM. | Cell Discovery

Fig. 3: Characterization of cardiac neutrophils at different stages of FM.

From: Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Fig. 3

a, b UMAP embedding of neutrophils colored by manually annotated clusters (a) and samples (b). c Violin plot showing the expression levels of cell typing genes in each neutrophil subtype. d Cell proportion change of neutrophils at different time points. e Bar plot showing the total cell number of each sample. f GO analysis of specifically expressed genes in each neutrophil subtype. g UMAP plot of neutrophils’ developmental transition as revealed by RNA velocity. h Box plot of characteristic scores among different neutrophil subclusters. Scores were calculated by AddModuleScore function of the Seurat package. i Immunofluorescence staining of Cxcl3 in the heart sample of FM mice at day 4. Scale bars: 50 μm (20 μm in the zoomed image).

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