Fig. 4: Characterization of peripheral neutrophils at different stages of FM. | Cell Discovery

Fig. 4: Characterization of peripheral neutrophils at different stages of FM.

From: Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Fig. 4

a–c UMAP embedding of peripheral blood immune cells colored by manually annotated clusters. UMAP embedding of peripheral neutrophils colored by manually annotated clusters (b) and samples (c). d FeaturePlot of marker genes of cardiac neutrophils. e GO analysis of specifically expressed genes in peripheral neutrophil clusters. f Cell proportion change of peripheral neutrophils at different time points. g Immunofluorescence staining of peripheral neutrophils at different time points. Scale bars: 20 μm. h, i Developmental trajectories of cardiac and peripheral neutrophils at day 7 colored by pseudotime (h) and cell types (i). j Spearman correlation of cardiac and peripheral neutrophil subtypes. k Box plot of characteristic scores of peripheral neutrophils at different time points. l Box plot of characteristic scores between cardiac and peripheral neutrophils.

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