Fig. 5: Functions of cardiac neutrophils. | Cell Discovery

Fig. 5: Functions of cardiac neutrophils.

From: Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Fig. 5

a Bubble plot showing the intercellular communication of chemotaxis among neutrophils and monocyte/macrophage subtypes, using CellChat working flow. b Heatmap showing the chemotaxis effects among cardiac neutrophil clusters through Cxcl–Cxcr. c, d The expression levels of Cxcl2 (c) and Cxcl3 (d) in the peripheral blood of patients with FM. e Correlation between the levels of Cxcl2 and Cxcl3 in the peripheral blood of patients with FM. f Interaction strength of ligand–receptor pairs between any pair of two cell populations among neutrophils and CM subclusters at day 4. g Heatmap showing the expression of ligand genes expressed in cardiac neutrophils at day 4 (left) and the regulated trajectory gene of those ligand expressions in CMs (right). h The expression of Tnf in each cardiac neutrophil cluster. i, j The relative expression of marker genes of FCs (i) and transcriptional factors (j) in cardiomyocytes of at different groups.

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