Fig. 6: Selective pressure mediated by M10 CAR-T cells. | Cell Discovery

Fig. 6: Selective pressure mediated by M10 CAR-T cells.

From: Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study

Fig. 6

a Neighbor-joining phylogenetic trees were constructed using aligned Env sequences amplified from replication-competent viruses in latent reservoir prior to (red) or post (blue) M10 CAR-T treatment. b Maximum likelihood phylogenetic trees were constructed using aligned protease and adverse transcriptase (PR/RT) region sequences. Bar graphs show the abundance of each identical sequence and the population it represents in pre-treatment or post-treatment viral reservoir. Sequences from pre-treatment samples are shown in red, and sequences from post-treatment samples were shown in blue.

Back to article page