Fig. 6: G-protein coupling of MCHR1 and MCHR2.
From: Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors
a Structural alignment between MCHR1‒Gi and MCHR2‒Gq complexes. b, c Comparative analysis of the Gα conformation in the α5 (b) and αN (c) domains. d Key residues in MCHR1 and MCHR2 that interact with the downstream Gαi or Gαq proteins. e Detailed interactions between the ICL2 of MCHR1 and MCHR2 with the αN ___domain of Gαi or Gαq. f IP-one assay data for wild-type and T22134.54R of MCHR1, with data presented as mean values ± SEM from three independent experiments performed in triplicate.
