Fig. 6: Heterogeneity of immune infiltration in tumor nest vs tumor stroma of SCLC. | Cell Discovery

Fig. 6: Heterogeneity of immune infiltration in tumor nest vs tumor stroma of SCLC.

From: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer

Fig. 6

a, b UMAP dimensionality reduction plot visualizing WTA data from each tumor nest ROI (a) and each tumor stroma ROI (b). The colors of the dots represent clusters classified by Gaussian mixture modeling. c, e Genes that change with pseudo-time were visualized using heatmaps of their corresponding expression levels in tumor nest ROIs (c) and tumor stroma ROIs (e). d, f Enriched pathways of DEGs identified in tumor ROIs (c) and tumor stroma ROIs (f). g K-means clustering of protein levels in tumor ROIs aggregated by patient IDs. h Heatmap of proteins that are differentially expressed in two groups, identified using K-means clustering.

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