Fig. 2: The morphological alterations of ovaries and uteruses in naturally aging monkeys after M-cell transplantation.
From: Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys
a Experimental design for naturally aging cynomolgus monkeys in the control and treated group. b, c Ultrasound observation of the ovaries (b) and statistics of the ovarian diameters (c) before treatment. The yellow frames highlighted the regions zoomed in. White broken circles represented the ovaries. White arrows referred to the maximal widths and maximal lengths of the ovaries. Scale bars, 2 mm. n = 3 monkeys (control), n = 7 monkeys (treated). ns no significance (two-tailed t-test). d, e Ultrasound observation of the ovaries (1 month after treatment) (d) as well as statistics of ovarian diameters in control and treated groups. The final value for each monkey is the average of six measurements taken at 1, 2, 3, 4, 5, and 6 months of treatment (e). The yellow frames highlighted the regions zoomed in. White broken circles represented the ovaries. White arrows referred to the maximal widths and maximal lengths of the ovaries. Scale bars, 2 mm. n = 3 monkeys (control), n = 6 monkeys (treated, except the pregnant monkey T02), *P < 0.05 (two-tailed t-test). f, g Ultrasound observation of the uteri (f) and statistics of the endometrial thicknesses of naturally aging monkeys (g) before treatment. The yellow frames highlighted the regions zoomed in. White broken circles represented the uteri. White arrows referred to the endometrial thicknesses. Scale bars, 5 mm. n = 3 monkeys (control), n = 7 monkeys (treated). ns, no significance (two-tailed t-test). h, i Ultrasound observation of the uteri (4 months after treatment) (h) as well as statistics of endometrial thicknesses in control and treated groups. The final value for each monkey is the average of six measurements taken at 1, 2, 3, 4, 5, and 6 months of treatment (i). The yellow frames highlighted the regions zoomed in. White broken circles represented the uteri. White arrows referred to the endometrial thicknesses. Scale bars, 5 mm. n = 3 monkeys (control), n = 6 monkeys (treated, except the pregnant monkey T02). *P < 0.05 (two-tailed t-test).
