Fig. 7: Schematic illustration of proposed working model of how hEnSC transplantation affects liver microenvironments. | Cell Research

Fig. 7: Schematic illustration of proposed working model of how hEnSC transplantation affects liver microenvironments.

From: Human endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling

Fig. 7

hEnSCs attract MoMFs/Kupffer cells in ALF livers and secrete CST1 in a paracrine fashion to suppress the IFN-induced pro-inflammatory macrophage polarization, and to promote the reprogramming of MoMFs/Kupffer cells into anti-inflammatory phenotypes by IL10, which finely tunes the immune microenvironments to accelerate the resolution of inflammation.

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