Fig. 8

Chemokine molecules as potential noninvasive biomarkers. Heatmaps showing that differential expression of chemokines and receptors in tumor tissues from cancer patients compared to normal controls (A) or in COVID-19 specimens compared to healthy controls (B). The significant differences in between tumor tissues and normal tissues are shown in red (upregulation) or blue (downregulation) ( | log2FC | >1 & adjusted p value < 0.05). The data were downloaded from the Bbcancer database (http://bbcancer.renlab.org). The total sample number (tumor and normal samples) is shown at the bottom right. The color bars on the top indicate the sample type (yellow: CTCs; green: blood; blue: extracellular vesicles, EVs)