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Effects of 10 weeks of walking-based exercise training on resting substrate oxidation in postmenopausal women with obesity

European Journal of Clinical Nutrition volume 79, pages 311–319 (2025)Cite this article

Subjects

Abstract

Background and aims

Accumulating evidence supports the effectiveness of moderate-intensity aerobic training on metabolic health, with limited studies investigating change in resting substrate oxidation. The aim of this study was to explore whether 10 weeks of walking-based aerobic training would alter substrate oxidation in postmenopausal women with obesity.

Methods and results

Twenty-four postmenopausal women with obesity who were assigned into the control (n = 12) or exercise groups (n = 12) undertook a 10-week aerobic training program (3 d·week−1) that involved walking exercises at 50–70% of heart rate reserve on a treadmill, with exercise volume increased from 25 to 40 min·day−1. Resting metabolic rate (RMR) and body composition were measured pre- and post-training. Whole-body substrate oxidation was calculated using respiratory data collected during RMR measurement via indirect calorimetry. No significant change was noted (p > 0.05) in resting fat oxidation and carbohydrate oxidation in the exercise group. Resting respiratory exchange ratio and RMR did not alter in response to the training program (p > 0.05).

Conclusion

Our results show that a 10-week of moderate-intensity aerobic training does not modify substrate oxidation in postmenopausal women with obesity.

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Fig. 1
Fig. 2
Fig. 3: Fat and carbohydrate oxidation data by group and time.
Fig. 4: Resting RER and RMR data by group and time.

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Data availability

All data generated or analyzed during this study are included in this article. Further enquiries can be directed to the corresponding author.

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Acknowledgements

The authors would like to thank Beytepe Gün Hospital for their contributions and support. We acknowledge the Hacettepe University Scientific Research Projects Coordination Unit for funding this study (Project ID: THD-2016-7280).

Funding

This study was funded by a grant from the Hacettepe University Scientific Research Projects Coordination Unit (Project ID: THD-2016-7280).

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  1. Division of Exercise Nutrition and Metabolism, Faculty of Sport Sciences, Hacettepe University, Ankara, Türkiye

    Yasemin Güzel, Muhammed Mustafa Atakan, Hüseyin Hüsrev Turnagöl & Şükran Nazan Koşar

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  1. Yasemin Güzel
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  2. Muhammed Mustafa Atakan
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YG, MMA, HHT, and ŞNK designed the study. YG and MMA collected and analyzed the data, and wrote the manuscript; HHT contributed to the interpretation of the results, constructing the methods, and reviewing the data analyses; ŞNK contributed to the development of the study idea, data collection, data analysis, and manuscript preparation. All authors have read and approved the final version of the manuscript, and agree with the order of presentation of the authors.

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Correspondence to Yasemin Güzel.

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This study was approved by the Hacettepe University Non-Interventional Clinical Research Ethics Board (GO: 15/197-33) and written informed consent was obtained from the participants.

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Güzel, Y., Atakan, M.M., Turnagöl, H.H. et al. Effects of 10 weeks of walking-based exercise training on resting substrate oxidation in postmenopausal women with obesity. Eur J Clin Nutr 79, 311–319 (2025). https://doi.org/10.1038/s41430-024-01546-1

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