Table 2 The numbers of reimbursed days of sickness absence among individuals with neurofibromatosis 1 (NF1) and matched controls.
ICD-10 chapter (ICD-10 codes) | Number of individuals with sickness allowance in the NF1 cohort of 850 individuals, n (%) | Number of individuals with sickness allowance in the control cohort of 9423 individuals, n (%) | Number of reimbursed days of sickness out of the total of 66,065 days in the NF1 cohort, n (%) | Number of reimbursed days of sickness out of the total of 458,436 days in the control cohort, n (%) | The counts of reimbursed days of sickness in NF1 vs. control cohort, RR (95% CI) |
|---|---|---|---|---|---|
Certain infectious and parasitic diseases (A00-B99) | 9 (1.1) | 109 (1.2) | 60 (0.1) | 2182 (0.5) | 0.34 (0.26–0.44) |
Neoplasms (C00-D48) | 99 (11.6) | 284 (3.0) | 13,336 (20.2) | 28,097 (6.1) | 7.41 (7.25–7.57) |
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) | 4 (0.5) | 12 (0.1) | 236 (0.4) | 378 (0.1) | 11.45 (9.56–13.7) |
Endocrine, nutritional and metabolic diseases (E00-E90) | 14 (1.6) | 70 (0.7) | 652 (1.0) | 3969 (0.9) | 1.91 (1.75–2.07) |
Mental and behavioral disorders (F00-F99) | 112 (13.2) | 1089 (11.6) | 11,300 (17.1) | 110,391 (24.1) | 1.29 (1.26–1.31) |
Diseases of the nervous system (G00-G99) | 35 (4.1) | 297 (3.2) | 3205 (4.9) | 19,051 (4.2) | 2.08 (2.00–2.16) |
Diseases of the eye and adnexa, ear and the mastoid process (H00-H95) | 14 (1.6) | 119 (1.3) | 210 (0.3) | 3892 (0.8) | 0.58 (0.50–0.67) |
Diseases of the circulatory system (I00-I99) | 31 (3.6) | 302 (3.2) | 3311 (5.0) | 19,254 (4.2) | 2.28 (2.19–2.37) |
Diseases of the respiratory system (J00-J99) | 30 (3.5) | 426 (4.5) | 569 (0.9) | 8175 (1.8) | 0.92 (0.85–1.00) |
Diseases of the digestive system (K00-K93) | 30 (3.5) | 379 (4.0) | 890 (1.3) | 9624 (2.1) | 1.13 (1.05–1.21) |
Diseases of the skin and subcutaneous tissue (L00-L99) | 8 (0.9) | 100 (1.1) | 136 (0.2) | 3318 (0.7) | 0.53 (0.44–0.63) |
Diseases of the musculoskeletal system and connective tissue (M00-M99) | 134 (15.8) | 1575 (16.7) | 11,177 (16.9) | 140,979 (30.8) | 1.04 (1.02–1.06) |
Diseases of the genitourinary system (N00-N99) | 16 (1.9) | 201 (2.1) | 235 (0.4) | 4467 (1.0) | 0.63 (0.55–0.72) |
Pregnancy, childbirth and the puerperium (O00-O99) | 24 (2.8) | 292 (3.1) | 960 (1.5) | 8940 (2.0) | 1.28 (1.20–1.37) |
Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) | 124 (14.6) | 18 (0.2) | 11,323 (17.1) | 1024 (0.2) | 462 (425–504) |
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99) | 20 (2.4) | 187 (2.0) | 1065 (1.6) | 5080 (1.1) | 2.84 (2.65–3.04) |
Injury, poisoning and certain other consequences of external causes (S00-T98) | 72 (8.5) | 1067 (11.3) | 3500 (5.3) | 53,735 (11.7) | 0.79 (0.77–0.82) |
