Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Clinical characteristics of dome-shaped macula in mild myopic or non-myopic eyes

Eye volume 39, pages 1787–1792 (2025)Cite this article

Subjects

Abstract

Objectives

To investigate dome-shaped macula (DSM) in mild myopic or non-myopic eyes.

Methods

Participants aged 50 years or older were recruited from July 2023 to August 2023. Clinical features including age, sex, visual acuity (VA), spherical equivalent refraction (SER), ocular biometry parameters, SS-OCT parameters and macular complications were compared between eyes with and without DSM. Logistic analysis was performed to explore risk factors for DSM.

Results

923 eyes were enrolled in the final analysis. The overall prevalence of DSM was 3.03% (28/923). Among eyes with DSM, 13 eyes (46.4%) were emmetropia, 9 eyes (32.1%) were hypermetropia, and 6 eyes (21.4%) were myopia, with 4 eyes (14.3%) were mild myopia and one eye (3.6%) was moderate myopia. The mean subfoveal choroidal thickness (SFCT) in eyes with DSM was 168.00 ± 77.79μm, which was significantly thinner than their counterparts absent of DSM (289.11 ± 95.58μm, p < 0.001). Logistic regression revealed that longer AL (odds ratio (OR) = 1.716, 95%CI: 1.205-2.442, p = 0.003) and female sex (OR = 3.330, 95% CI: 1.109-10.005, p = 0.032) were associated with DSM. No vitreomacular complication including epiretinal membrane (ERM), vitreomacular traction (VMT), lamellar macular hole (LMH) and full-thickness macular hole (FTMH) was found in eyes with DSM, while the overall prevalence of those macular complications in eye without DSM was 8.8% (79/895).

Conclusions

The study offered a detailed profile of DSM in mild myopic or non-myopic eyes and found a diffuse thinning of choroid in both foveal and parafoveal area in eyes with DSM. No case with vitreomacular complications was identified in DSM eyes in our study population.

Trail registration

The registration number of the present trial in the Chinese Clinical Trial Registry is ChiCTR2000037944.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Representative OCT scans of eyes with DSM in different refractory status.

Similar content being viewed by others

Data availability

The data are stored in the form of paper materials in the Epi-data database, which are available on reasonable request.

References

  1. Gaucher D, Erginay A, Lecleire-Collet A, Haouchine B, Puech M, Cohen SY, et al. Dome-shaped macula in eyes with myopic posterior staphyloma. Am J Ophthalmol. 2008;145:909–14.

    Article  PubMed  Google Scholar 

  2. Zhao X, Ding X, Lyu C, Li S, Lian Y, Chen X, et al. Observational study of clinical characteristics of dome-shaped macula in Chinese Han with high myopia at Zhongshan Ophthalmic Centre. BMJ Open. 2018;8:e021887.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Fang D, Zhang Z, Wei Y, Wang L, Zhang T, Jiang X, et al. The morphological relationship between dome-shaped macula and myopic retinoschisis: a cross-sectional study of 409 highly myopic eyes. Invest Ophthalmol Vis Sci. 2020;61:19.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Coco RM, Sanabria MR, Alegria J. Pathology associated with optical coherence tomography macular bending due to either dome-shaped macula or inferior staphyloma in myopic patients. Ophthalmologica. 2012;228:7–12.

    Article  PubMed  Google Scholar 

  5. Liang IC, Shimada N, Tanaka Y, Nagaoka N, Moriyama M, Yoshida T, et al. Comparison of clinical features in highly myopic eyes with and without a dome-shaped macula. Ophthalmology. 2015;122:1591–1600.

    Article  PubMed  Google Scholar 

  6. Jain M, Gopal L, Padhi TR. Dome-shaped maculopathy: a review. Eye (Lond). 2021;35:2458–67.

    Article  PubMed  Google Scholar 

  7. Kumar V, Verma S, Azad SV, Chawla R, Bhayana AA, Surve A, et al. Dome-shaped macula-review of literature. Surv Ophthalmol. 2021;66:560–71.

    Article  PubMed  Google Scholar 

  8. Errera MH, Michaelides M, Keane PA, Restori M, Paques M, Moore AT, et al. The extended clinical phenotype of dome-shaped macula. Graefes Arch Clin Exp Ophthalmol. 2014;252:499–508.

    Article  PubMed  Google Scholar 

  9. Dormegny L, Liu X, Philippakis E, Tadayoni R, Bocskei Z, Bourcier T, et al. Evolution of dome-shaped macula is due to differential elongation of the eye predominant in the peri-dome region. Am J Ophthalmol. 2021;224:18–29.

    Article  PubMed  Google Scholar 

  10. Giordano L, Friedman DS, Repka MX, Katz J, Ibironke J, Hawes P, et al. Prevalence of refractive error among preschool children in an urban population: the Baltimore Pediatric Eye Disease Study. Ophthalmology. 2009;116:739–46 746.e731-734.

    Article  PubMed  Google Scholar 

  11. Muller PL, Kihara Y, Olvera-Barrios A, Warwick AN, Egan C, Williams KM, et al. Quantification and predictors of OCT-based macular curvature and dome-shaped configuration: results from the UK Biobank. Invest Ophthalmol Vis Sci. 2022;63:28.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Iribarren R. Crystalline lens and refractive development. Prog Retin Eye Res. 2015;47:86–106.

    Article  PubMed  Google Scholar 

  13. Zhang Y, Zhang Q, Li SZ, He MG, Li SN, Wang NL. Anterior segment characteristics and risk factors for primary angle closure disease with long axial lengths: the handan eye study. Invest Ophthalmol Vis Sci. 2023;64:8.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ellabban AA, Tsujikawa A, Matsumoto A, Yamashiro K, Oishi A, Ooto S, et al. Three-dimensional tomographic features of dome-shaped macula by swept-source optical coherence tomography. Am J Ophthalmol. 2013;155:320–328 e322.

    Article  PubMed  Google Scholar 

  15. Ohsugi H, Ikuno Y, Oshima K, Yamauchi T, Tabuchi H. Morphologic characteristics of macular complications of a dome-shaped macula determined by swept-source optical coherence tomography. Am J Ophthalmol. 2014;158:162–170 e161.

    Article  PubMed  Google Scholar 

  16. Caillaux V, Gaucher D, Gualino V, Massin P, Tadayoni R, Gaudric A. Morphologic characterization of dome-shaped macula in myopic eyes with serous macular detachment. Am J Ophthalmol. 2013;156:958–967.e951.

    Article  PubMed  Google Scholar 

  17. Shin E, Park KA, Oh SY. Dome-shaped macula in children and adolescents. PLoS One. 2020;15:e0227292.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Garcia-Ben A, Kamal-Salah R, Garcia-Basterra I, Gonzalez Gomez A, Morillo Sanchez MJ, Garcia-Campos JM. Two- and three-dimensional topographic analysis of pathologically myopic eyes with dome-shaped macula and inferior staphyloma by spectral ___domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2017;255:903–12.

    Article  PubMed  Google Scholar 

  19. Imamura Y, Iida T, Maruko I, Zweifel SA, Spaide RF. Enhanced depth imaging optical coherence tomography of the sclera in dome-shaped macula. Am J Ophthalmol. 2011;151:297–302.

    Article  PubMed  Google Scholar 

  20. Dai F, Li S, Wang Y, Li S, Han J, Li M, et al. Correlation between posterior staphyloma and dome-shaped macula in high myopic eyes. Retina. 2020;40:2119–26.

    Article  PubMed  Google Scholar 

  21. Fajardo Sanchez J, Chau Ramos CE, Roca Fernandez JA, Urcelay Segura JL. Clinical, fundoscopic, tomographic and angiographic characteristics of dome shaped macula classified by bulge height. Arch Soc Esp Oftalmol. 2017;92:458–63.

    CAS  PubMed  Google Scholar 

  22. Chebil A, Ben Achour B, Chaker N, Jedidi L, Mghaieth F, El Matri L. [Choroidal thickness assessment with SD-OCT in high myopia with dome-shaped macula]. J Fr Ophtalmol. 2014;37:237–41.

    Article  CAS  PubMed  Google Scholar 

  23. Viola F, Dell’Arti L, Benatti E, Invernizzi A, Mapelli C, Ferrari F, et al. Choroidal findings in dome-shaped macula in highly myopic eyes: a longitudinal study. Am J Ophthalmol. 2015;159:44–52.

    Article  PubMed  Google Scholar 

  24. Soudier G, Gaudric A, Gualino V, Massin P, Nardin M, Tadayoni R, et al. Macular choroidal thickness in myopic eyes with and without a dome-shaped macula: a case-control study. Ophthalmologica. 2016;236:148–53.

    Article  PubMed  Google Scholar 

  25. Keane PA, Mitra A, Khan IJ, Quhill F, Elsherbiny SM. Dome-shaped macula: a compensatory mechanism in myopic anisometropia? Ophthalmic Surg Lasers Imaging. 2012;43:e52–54.

    Article  PubMed  Google Scholar 

  26. Lee GW, Kim JH, Kang SW, Kim J. Structural profile of dome-shaped macula in degenerative myopia and its association with macular disorders. BMC Ophthalmol. 2020;20:202.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Zhu X, He W, Zhang S, Rong X, Fan Q, Lu Y. Dome-shaped macula: a potential protective factor for visual acuity after cataract surgery in patients with high myopia. Br J Ophthalmol. 2019;103:1566–70.

    Article  PubMed  Google Scholar 

  28. Mirza RG, Johnson MW, Jampol LM. Optical coherence tomography use in evaluation of the vitreoretinal interface: a review. Surv Ophthalmol. 2007;52:397–421.

    Article  PubMed  Google Scholar 

Download references

Funding

The study was funded by the Capital’s Funds for Health Improvement and Research (Grant No. 2022-1-2052).

Author information

Authors and Affiliations

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China

    Mengyang Li, Zhi Li, Fei Xiang, Ye Zhang & Shuning Li

  2. Shaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital), Xi’an, China

    Caixia Li

Authors
  1. Mengyang Li
    View author publications

    Search author on:PubMed Google Scholar

  2. Zhi Li
    View author publications

    Search author on:PubMed Google Scholar

  3. Fei Xiang
    View author publications

    Search author on:PubMed Google Scholar

  4. Caixia Li
    View author publications

    Search author on:PubMed Google Scholar

  5. Ye Zhang
    View author publications

    Search author on:PubMed Google Scholar

  6. Shuning Li
    View author publications

    Search author on:PubMed Google Scholar

Contributions

SL designed the study; SL, CL and ML conducted the study and examined the subjects; ML, FX and ZL analysed the images and data; YZ provided advice on the data analyses; ML wrote the manuscript; SL reviewed and edited the manuscript; SL is the guarantor for the text in this article.

Corresponding author

Correspondence to Shuning Li.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics approval

The study was approved by the Beijing Tongren Hospital Ethics Committee, Capital Medical University (Approval No. TRECKY2019-071). The procedure was performed in accordance with the principles of the Declaration of Helsinki. The informed consent form was signed by all participants attending this study. The registration number in the Chinese Clinical Trial Registry is ChiCTR2000037944.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, M., Li, Z., Xiang, F. et al. Clinical characteristics of dome-shaped macula in mild myopic or non-myopic eyes. Eye 39, 1787–1792 (2025). https://doi.org/10.1038/s41433-025-03756-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41433-025-03756-8

Search

Advanced search

Quick links