Fig. 3: ETI and LV-CFTR treatment show comparable efficacy in restoring CFTR function. | Gene Therapy

Fig. 3: ETI and LV-CFTR treatment show comparable efficacy in restoring CFTR function.

From: Lentiviral vector gene therapy and CFTR modulators show comparable effectiveness in cystic fibrosis rat airway models

Fig. 3

Representative Isc traces from A ALIs derived from wild-type, Phe508del and KO airway epithelial cells, B untreated Phe508del and ETI-treated rat ALI cultures, C Phe508del LV-CFTR treated ALI culture compared to untreated Phe508del and D KO LV-CFTR treated ALI culture compared to untreated KO. E ΔIsc forskolin response in wild-type, Phe508del, KO, Phe508del treated with ETI, and Phe508del and KO treated with LV-CFTR. Data are represented as mean ± SEM, one-way ANOVA, Tukey’s multiple comparison test, ns: not significant, **p < 0.01, ***p < 0.001, ****p < 0.0001, n = 5-14 per group. Each data point represents an individual animal. F508; Phe508del.

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