Fig. 2: HIV antibody functions.
From: Fc receptors and the diversity of antibody responses to HIV infection and vaccination
The functions are dependent on different Ab domains: The Fab ___domain is involved in virus neutralization, opsonization and aggregation; the Fc ___domain of Ab induces the activation of the complement system; dual binding of Ab via Fab and Fc domains leads to Fc-mediated antibody function: antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity; FcR internalization may lead to phagocytosis, antigen presentation or antibody-dependent enhancement.
