Fig. 1: Genetic disruption of mitochondrial metabolism drives ROS-HIF1α dependent exhaustion programs in CD8+ T cells.
From: Take my breath away—mitochondrial dysfunction drives CD8+ T cell exhaustion
Impairment of mitochondrial fitness represents a key infliction point of CD8+ T cell exhaustion in response to viral chronic infection. This implicates drugs targeting CD8+ T cell metabolism as an important new avenue to increase immune checkpoint inhibition and CAR T cell therapies.
