Table 3 Multivariate analysis of SNPs associated with the development of infectious events following induction chemotherapy.
A. Stratification cohort (n = 186) | |||
|---|---|---|---|
Genetic variable | Sepsis; OR (95% CI), p value | Pneumonia; OR (95% CI), p value | IFD ; OR (95% CI), p value |
TLR4 399 rs4986791 | 0.70 (0.28–1.75) 0.439 | 1.17 (0.45–3.04) 0.754 | 1.38 (0.47–4.11) 0.562 |
TLR2 Arg753Gln rs5743708 | 4.26 (0.91–20.0) 0.067 | 9.52 (1.96–46.23), 0.005 | 4.27 (1.23–14.81), 0.02 |
Dectin-1 Y238X rs 16910526 | 1.81 (0.66–4.99) 0.252 | 0.79 (0.28–2-27) 0.673 | 0.79 (0.24–2.57) 0.688 |
Dectin-1 rs7309123 G/G genotype | 1.55 (0.78–3.07) 0.208 | 2.33 (1.14–4.76), 0.020 | 2.33 (1.12–4.86), 0.024 |
Dectin-1 rs7309123 G/G + C/G genotype | 2.84 (1.42–5.67), 0.003 | 3.17 (1.43–7.04), 0.004 | 2.81 (1.15–6.87), 0.024 |
DC-SIGN rs4804800 G/A + G/G genotype | 2.37 (1.19–4.72), 0.015 | 2.26 (1.15–4.46), 0.019 | 1.93 (0.94–3.98) 0.075 |
DC-SIGN rs7248637 A/G + A/A genotype | 1.94 (0.91–4.14) 0.852 | 1.91 (0.90–4.04) 0.913 | 1.91 (0.87–4.19) 0.114 |
PTX3 rs3816527 A/A + A/C genotype | 0.89 (0.49–1.61) 0.693 | 0.98 (0.52–1.86) 0.961 | 0.98 (0.49–1.98) 0.970 |
PTX3 rs2305619 A/A + G/A genotype | 1.29 (0.66–2.53) 0.457 | 0.91 (0.45–1.87) 0.806 | 1.05 (0.47–2.34) 0.910 |
PTX3 rs1840680 A/A + G/A genotype | 1.36 (0.63–2.94) 0.433 | 0.93 (0.41–3.0) 0.855 | 1.04 (0.42–2.58) 0.941 |
Ficolin 2 rs17514136 G/G genotype | 1.44 (0.57–3.62) 0.439 | 2.67 (1.04–6.82), 0.040 | 0.97 (0.35–2.73) 0.955 |
Ficolin 2 rs17514136 G/G + A/G genotype | 1.93 (1.06–3.51), 0.032 | 1.26 (0.68–2.33) 0.471 | 0.95 (0.48–1.86) 0.872 |
Ficolin 2 rs17514136 A/A + G/A genotype | 0.71 (0.28–1.82) 0.472 | 0.84 (0.56–3.64) 0.365 | 1.03 (0.37–2.90) 0.955 |
Ficolin 2 rs17549193 T/T genotype | 1.44 (0.57–3.62) 0.439 | 2.83 (1.10–7.23), 0.030 | 1.03 (0.37–2.90) 0.952 |
Ficolin 2 rs17549193 T/T + C/T genotype | 1.92 (1.1–3.45), 0.031 | 1.27 (0.68–2.37) 0.449 | 1.03 (0.52–2.03) 0.943 |
B. Validation cohort (n = 138) | |||
|---|---|---|---|
TLR4 399 rs4986791 | 0.43 (0.16–1.14) 0.09 | 0.55 (0.19–1.62) 0.276 | 0.26 (0.06–1.19) 0.082 |
TLR2 Arg753Gln rs5743708 | 1.17 (0.33–4.22) 0.805 | 0.94 (0.26–3.38) 0.925 | 1.50 (0.41–5.45) 0.54 |
Dectin-1 Y238X rs 16910526 | 1.94 (0.75–5.03) 0.173 | 2.05 (0.85–4.94) 0.110 | 2.88 (1.17–7.08), 0.021 |
Dectin-1 rs7309123 G/G genotype | 1.03 (0.44–2.41) 0.945 | 1.09 (0.47–2.55) 0.844 | 1.26 (0.51–3.10) 0.610 |
Dectin-1 rs7309123 G/G + C/G genotype | 1.46 (0.72–2.98) 0.296 | 1.16 (0.56–2.40) 0.689 | 1.52 (0.67–2.41) 0.310 |
DC-SIGN rs4804800 G/A | 3.49 (1.40–8.71), 0.07 | 1.57 (0.72–3.41) 0.258 | 1.02 (0.44–2.39) 0.962 |
DC-SIGN rs7248637 A/G genotype | 1.73 (0.75–3.98) 0.202 | 1.53 (0.69–3.39) 0.292 | 0.76 (0.31–1.88) 0.557 |
PTX3 rs3816527 C/C + A/C genotype | 3.37 (1.61–7.06), 0.001 | 4.54 (1.09–10.86), 0.001 | 4.89 (1.76–13.58), 0.002 |
PTX3 rs2305619 A/A + A/C genotype | 2.88 (1.25–6.61), 0.013 | 7.48 (2.14–26.13), 0.002 | 7.30 (1.65–32.33), 0.009 |
PTX3 rs1840680 A/A + G/A genotype | 2.88 (1.25–6.61), 0.013 | 7.48 (2.14–26.13), 0.002 | 7.30 (1.65–32.33), 0.009 |
Ficolin 2 rs17514136 G/G genotype | 0.56 (0.73–1.59) 0.295 | 0.53 (0.10–2.75) 0.452 | 0.84 (0.16–4.34) 0.833 |
Ficolin 2 rs17514136 G/G + A/G genotype | 0.99 (0.49–1.99) 0.977 | 1.73 (0.86–3.49) 0.126 | 1.47 (0.68–3.04) 0.344 |
Ficolin 2 rs17514136 A/A + G/A genotype | 11.96 (1.43–100.16), 0.022 | 1.86 (0.36–9.66) 0.452 | 1.19 (0.23–6.18) 0.833 |
Ficolin 2 rs17549193 T/T genotype | 0.31 (0.73–1.28) 0.115 | 1.35 (0.35–5.27) 0.666 | 1.29 (0.31–5.44) 0.727 |
Ficolin 2 rs17549193 T/T + C/T genotype | 0.99 (0.49–1.98) 0.977 | 1.73 (0.86–3.49) 0.126 | 1.44 (0.68–3.04) 0.344 |
