Fig. 1
From: The functional impact of variants of uncertain significance in BRCA2
Position of BRCA2 variants. Schematic representation of the position of class 1/2 variants (green dots), class 4/5 variants (red dots), and BRCA2 variants of uncertain significance (VUS) (gray dots) in the BRCA2 gene. Ta transcriptional activation ___domain, P phosphorylation site, H helical ___domain, DBD DNA binding ___domain, OB oligonucleotide binding fold, T Tower ___domain, TR2 C-terminal RAD51 binding site, NLS nuclear localization signal, aa amino acids19,39,40
