Fig. 3
From: Comorbidity landscape of the Danish patient population affected by chromosome abnormalities
Comorbidity distributions and life expectancy of Down syndrome (DS), Klinefelter syndrome (KS), and Turner syndrome (TS) patients. a The age at first diagnosis (x-axis) versus percentage of patients diagnosed (y-axis) for DS, KS, and TS. DS patients are usually diagnosed in early life, TS patients are usually diagnosed during childhood, and KS patients are usually diagnosed at the age of trying to conceive, with the peak around age 30. See Fig. 1 for color scheme. b The relative comorbidity burden over the past 20 years for DS, KS, and TS. Again, the colors correspond to the International Classification of Diseases version 10 (ICD-10) chapters (see Fig. 1). The names of the comorbidities displayed are as follows: E29 = Testicular dysfunction; F79 = Unspecified mental retardation; G40 = Epilepsy; H26 = Other cataract; H50 = Other strabismus; H52 = Disorders of refraction and accommodation; H65 = Nonsuppurative otitis media; H66 = Suppurative and unspecified otitis media; H90 = Conductive and sensorineural hearing loss; H91 = Other hearing loss; I10 = Essential (primary) hypertension; J18 = Pneumonia, organism unspecified; J35 = Chronic diseases of tonsils and adenoids; J45 = Asthma; K02 = Dental caries; M54 = Dorsalgia; M79 = Other soft tissue disorders, not elsewhere classified; N46 = Male infertility; N62 = Hypertrophy of breast; N97 = Female infertility; and Q21 = Congenital malformations of cardiac septa. c The change in life expectancy and median age of the patients in the registry per year for DS, KS, and TS. The life expectancy for DS and TS has increased over the past 20 years whereas the life expectancy for KS has not changed. The median age of the patients in the registry has slightly decreased for DS, but increased for KS and TS.
