Fig. 1

Change in cerebrospinal fluid opening pressure throughout treatment. Cerebrospinal fluid opening pressure on lumbar puncture decreased significantly from time point 1 to 2, i.e., prior to transplant (p = 0.0499). At time point 3, which is 100 days posttransplant, the opening pressure was also significantly lower than time point 1 (p = 0.0004). Opening pressure increased somewhat at time point 4, which is 6 months posttransplant, such that it was no longer significantly different from time point 1 (p = 0.0861).