Table 4 Predicted rates of mosaicism by age at presentation of bilateral vestibular schwannomas (BVS)

From: Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing

 

Number

Constitutional

%

Mosaic presumed from tumor or blood

No variant found

% No variant

Overall probable mosaic rate

BVS <20

175

136

77.71%

27

15.43%

12

6.86%

21.67%

BVS 20–29

114

69

60.53%

21

18.42%

24

21.05%

37.58%

BVS 30–39

110

48

43.64%

36

32.73%

26

23.64%

54.24%

BVS 40–49

79

23

29.11%

20

25.32%

36

45.57%

66.78%

BVS 50–59

69

11

15.94%

13

18.84%

45

65.22%

78.19%

BVS 60+

84

8

9.52%

5

5.95%

69

82.14%

80.70%

Total

631

295

46.75%

122

19.33%

212

33.60%

49.91%