Table 4 Diagnostic utility of individual measures for detecting iron deficiency (ID)a/ID anemia (IDA)b, % (95% confidence interval)
From: Detection of iron deficiency in children with Down syndrome
| Â | Â | Sensitivity | Specificity | PPV | NPV | ROC |
|---|---|---|---|---|---|---|
Low Hgb | ID | 0 (0–8) | 98 (97–99) | 0 (0) | 95 (94–95) | 0.49 |
IDA | 100 (69–100) | 99 (98–100) | 56 (39–71) | 100 (100) | 1.00 | |
Low MCV | ID | 9 (2–21) | 99 (97–99) | 25 (10–50) | 95 (95) | 0.54 |
IDA | 30 (7–65) | 98 (97–99) | 19 (7–41) | 99 (99) | 0.64 | |
High RDW | ID | 91 (79–98) | 91 (89–93) | 38 (32–44) | 99 (99–100) | 0.91 |
IDA | 100 (69–100) | 88 (86–90) | 9 (8–11) | 100 (100) | 0.94 | |
Low ferritin | ID | 28 (16–44) | 99 (97–99) | 50 (33–67) | 96 (95–97) | 0.64 |
IDA | 80 (44–97) | 98 (97–99) | 31 (20–44) | 100 (99–100) | 0.89 | |
Low ferritin (normal CRP) | ID | 50 (31–69) | 99 (98–100) | 79 (57–91) | 97 (96–98) | 0.75 |
IDA | 75 (19–99) | 97 (96–99) | 16 (8–28) | 100 (99–100) | 0.86 | |
Low TS | ID | 93 (82–99) | 86 (83–88) | 27 (24–31) | 100 (99–100) | 0.90 |
IDA | 80 (44–97) | 82 (80–85) | 5 (4–7) | 100 (99–100) | 0.81 | |
Low TS (normal CRP) | ID | 90 (73–98) | 87 (84–89) | 26 (22–31) | 99 (98–100) | 0.88 |
IDA | 100 (40–100) | 84 (80–86) | 4 (3–5) | 100 (100) | 0.92 |
