Fig. 4: Independent assessment of complete in vitro MMR activity (CIMRA) assay reproducibility. | Genetics in Medicine

Fig. 4: Independent assessment of complete in vitro MMR activity (CIMRA) assay reproducibility.

From: Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

Fig. 4

MSH6 variants and controls were tested for CIMRA assay activity in different centers worldwide (see legend in figure). The MSH6 p.G1139S variant is included in every experiment as a repair-deficient control.12, 17 Bars represent mean ± S.E.M. of 3–4 experiments. Numbers below the diagrams indicate the International Agency for Research on Cancer (IARC) classification. LUMC Leiden University Medical Center, QIMR QIMR Berghofer Medical Research Institute, WT wild type.

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