Fig. 1: Lack of correlation between changes in plasma lyso-Gb3 and changes in LVMi, eGFR, and pain at selected timepoints of migalastat treatment.

(a) Relationship between changes in lyso-Gb3 versus changes in LVMi. (b) Relationship between changes in lyso-Gb3 vs. changes in eGFR. (c) Relationship between changes in lyso-Gb3 versus changes in worst pain in 24 hours. eGFR estimated glomerular filtration rate, ERT enzyme replacement therapy, LVMi left ventricular mass index, lyso-Gb3 globotriaosylsphingosine, OLE open-label extension.