Fig. 4: Forest plot for effect of maintenance treatment (MT) adherence and development of insidious onset movement disorder (MD) in patients identified by newborn screening (NBS) including and excluding noninformative studies. | Genetics in Medicine

Fig. 4: Forest plot for effect of maintenance treatment (MT) adherence and development of insidious onset movement disorder (MD) in patients identified by newborn screening (NBS) including and excluding noninformative studies.

From: Impact of newborn screening and quality of therapy on the neurological outcome in glutaric aciduria type 1: a meta-analysis

Fig. 4

In contrast to noninformative studies, informative studies compare two different interventions groups within one study. Patients not following MT recommendations show a trend for increased relative risk (log risk ratio [RR]) for development of an insidious MD compared with patients with MT adherence (p = 0.058; log RR 0.61). This effect becomes clearly significant if noninformative studies are excluded (p < 0.0001) increasing the RR to almost exp(2) = 7. CI confidence interval, RE random effect. Including noninformative studies: test of heterogeneity: QM(df14) = 29.1436; model results: p = 0.0585. I2 (residual heterogeneity/unaccounted variability): 51.28%. Excluding noninformative studies: test for heterogeneity: Q(df = 1) = 0.1765; model results: p < 0.0001. I2 (residual heterogeneity/unaccounted variability): 0%.

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