Fig. 2: Predicted absolute risks of developing breast and ovarian cancer by polygenic risk score (PRS) percentile. | Genetics in Medicine

Fig. 2: Predicted absolute risks of developing breast and ovarian cancer by polygenic risk score (PRS) percentile.

From: Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Fig. 2

Risks were calculated assuming the retrospective cohort hazard ratio (HR) estimates (Tables 1, 2). (a) Predicted absolute risks of developing breast cancer for BRCA1 carriers by percentiles of the PRSER-. (b) Predicted absolute risks of developing breast cancer for BRCA2 carriers by percentiles of the PRSBC. (c) Predicted absolute risks of developing ovarian cancer for BRCA1 carriers by the percentiles of the PRSHGS. (d) Predicted absolute risks of developing ovarian cancer for BRCA2 carriers by percentiles of the PRSHGS. ER estrogen receptor, HGS high-grade serous.

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