Table 1 Results of the association analyses between breast cancer and the PRS₃₁₃.

	n Included	n Events	HR	95% CI	p value	C-statistic^c	95% CI
Main analyses	6522	320	1.56	1.40–1.74	2.47×10⁻¹⁵
Age category for discriminative ability of the PRS
<60	2175	104				0.632	0.58–0.69
60–70	2174	128				0.673	0.61–0.73
≥70	2173	88				0.562	0.48–0.62
Sensitivity analyses
Invasive BC only	6522	290^a	1.57	1.40–1.77	1.34 × 10⁻¹⁴
In situ BC only	6522	34	1.43	1.01–2.01	0.042
Censored at other tumor	6402^b	298	1.54	1.37–1.73	1.88 × 10⁻¹³
Stratified by RS cohort	6522	320	1.56	1.40–1.75	1.92 × 10⁻¹⁵
Percentage of the PRS
0–10%	637	17	0.59	0.34–1.01	0.053
10–20%	636	16	0.58	0.33–1.01	0.053
20–40%	1283	42	0.73	0.49–1.09	0.120
40–60%	1298	57	1.00	Reference	Reference
60–80%	1325	85	1.49	1.07–2.09	0.019
80–90%	656	36	1.28	0.84–1.94	0.251
90–100%	687	67	2.37	1.66–3.37	1.73 × 10⁻⁰⁶
Age category for time-varying analyses
<50	224	2	2.74	1.72–4.37	2.23 × 10⁻⁰⁵
50–75	5104	197	1.74	1.52–2.00	2.21 × 10⁻¹⁵
>75	4032	121	1.29	1.08–1.55	0.005

BC breast cancer, CI confidence interval, HR hazard ratio, PRS polygenic risk score, RS Rotterdam Study.
^a4 women developed an invasive breast tumor after development of an in situ breast tumor.
^b120 women were excluded from analyses because they developed another tumor before inclusion in the Rotterdam Study.
^cThe corresponding differences in C-statistic were for women with inclusion age 60–70 versus age <60: 0.041, 95% CI [−0.05–0.12]; for women with inclusion age 60–70 versus age ≥70: 0.111, 95% CI [0.02–0.21]; for women with inclusion age <60 versus age ≥70: 0.070, 95% CI [−0.01–0.18].

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