Fig. 3: Structural representation of human POLE and POLD1 and ___location of the ED variants identified in the current study. | Genetics in Medicine

Fig. 3: Structural representation of human POLE and POLD1 and ___location of the ED variants identified in the current study.

From: Role of POLE and POLD1 in familial cancer

Fig. 3

(a) 3D structure of POLE. (b) 3D structure of POLD1. Single-stranded DNA from the aligned bacteriophage T4 polymerase complex (PDB ID: 1NOY) is shown in yellow. Variants in the DNA binding pocket are highlighted in red.

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