Fig. 1: Brain imaging.
From: Normal early development in siblings with novel compound heterozygous variants in ASPM
a The older sister at 2 years of age. Three-dimensional CT (left), axial (middle), and sagittal (right) T1-weighted MRI. Metopic suture craniosynostosis led to trigonocephaly. Significant small frontal lobes, small pons, and enlarged lateral ventricles were observed. Cerebellar hypoplasia was not observed. b The younger brother at 6 months of age. The findings were similar to his sister’s, but he did not have lateral ventricle enlargement. Cerebellar hypoplasia was not observed, just as in his sister.
